The effect of salicylate on glycosuria, blood glucose and liver glycogen of the alloxan-diabetic rat.
نویسندگان
چکیده
Large doses of salicylates have been reported to prevent diabetic glycosuria inman and the drug was used in the treatment of diabetes during the latter part of the last century (Gross & Greenberg, 1948). The recent report of Ingle (1950) that aspirin reduced the glycosuria of rats made mildly diabetic by partial pancreatectomy stimulated us to investigate this effect in more detail. In the present work the effect of salicylate on the glycosuria, blood glucose and liver glycogen of rats made severely diabetic with alloxanwas studied. The blood glucose and liver glycogen of normal rats treated with salicylate were also investigated because LutwakMann (1942) reported a marked decrease in liver glycogen in such animals.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 51 1 شماره
صفحات -
تاریخ انتشار 1952